CHEMICAL MEDIATORS OF INFLAMMATION Definition:any messenger that acts on blood vessels,inflammatory cells or other cells to contribute to an inflammatory response.Exogenous 鈥ndotoxins Endogenous 鈥lasma 鈥eukocytes 鈥ndothelial cells 鈥ibroblastsCHEMICAL MEDIATORS OF INFLAMMATION
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What is the difference between chemical and cell-derived mediators of inflammation?
Chemical mediators of inflammation must have some comman properties as under: Either they should release from the cells or derived from the plasma proteins. Cell-derived mediators are released either from their storage in cell granules or synthesised inthe cells. Most common site of synthesis of plasma-derived mediated is the liver.
What are the mediators of acute inflammation?
The mediators of acute inflammation are classified into systems based on their source and/or chemical composition. Histamine, stored in granules in mast cells and released upon stimulation, accounts for the arteriolar dilatation and increased permeability of venules in the immediate transient phase.
What are chemical mediators of cell action?
Chemical action 鈥?one or many target cells with different effects. Chemical mediators are short lived and scavenge oxygen species. Histamine and serotonin cause tissue damage. Histamine is found in the granules of mast cells, basophils and platelets.
What are histamine mediators?
They are the first mediators to be released during inflammation. Once formed it can be either stored or rapidly inactivated. Derived from the decarboxylation of the amino acid histidine. 5. Mention the actions of Histamine